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Interoperative Optical Coherence Tomography

We are developing optical coherence tomography (OCT) for rapid intraoperative histology. OCT is a powerful, noninvasive microscopic imaging tool widely used for clinical diagnosis, particularly in ophthalmology and cardiology. Previously, we created needle beam (NB) technology to address the classic trade-off between resolution and depth-of-focus, enabling the rapid generation of 3D high-resolution images. We applied NB-OCT for skin cancer diagnosis and developed AI-based virtual histology imaging of living tissues.

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Currently, we have two ongoing projects. The first involves developing an NB-OCT endoscope in collaboration with the da Vinci surgical system. This project aims to detect neurovascular bundles (NVB) to protect them from damage during prostate cancer surgery. The second project focuses on building a full-field OCT for rapid intraoperative histology of tumor resection specimens based on innate cell vibrations. This label-free, cellular-resolution technique can analyze an area of 100 cm² within 10 minutes, enabling precise analysis of tumor margins and improving surgical outcomes.

 Selected Publications

  • Zhao, Jingjing, Aidan Van Vleck, Yonatan Winetraub, Lin Du, Yong Han, Sumaira Aasi, Kavita Yang Sarin, and Adam de la Zerda. "Rapid cellular-resolution skin imaging with optical coherence tomography using all-glass multifocal metasurfaces." ACS nano 17, no. 4 (2023): 3442-3451. [PDF]

  • Zhao, Jingjing, Yonatan Winetraub, Lin Du, Aidan Van Vleck, Kenzo Ichimura, Cheng Huang, Sumaira Z. Aasi, Kavita Y. Sarin, and Adam de la Zerda. "Flexible method for generating needle-shaped beams and its application in optical coherence tomography." Optica 9, no. 8 (2022): 859-867.[PDF]

  • Cao, Rui, Jingjing Zhao (co-first author), Lei Li, Lin Du, Yide Zhang, Yilin Luo, Laiming Jiang et al. "Optical-resolution photoacoustic microscopy with a needle-shaped beam." Nature Photonics 17, no. 1 (2023): 89-95. [PDF]

  • Guo, Xiangyu, Jingjing Zhao (co-first author), Liqun Sun, Varun Gupta, Lin Du, Komal Sharma, Aidan Van Vleck et al. "Visualizing cortical blood perfusion after photothrombotic stroke in vivo by needle-shaped beam optical coherence tomography angiography." PhotoniX 5, no. 1 (2024): 7.[PDF]

  • Winetraub, Yonatan (co-first author), Aidan Van Vleck (co-first author), Edwin Yuan (co-first author), Itamar Terem (co-first author), Jinjing Zhao, Caroline Yu, Warren Chan et al. "Noninvasive virtual biopsy using micro-registered optical coherence tomography (OCT) in human subjects." Science Advances 10, no. 15 (2024): eadi5794. [PDF]

  • Guo, Xiangyu, Xiaochen Li, Xinyue Wang, Mingxin Li, Xiaochuan Dai, Lingjie Kong, Qun Hao, Jingjing Zhao (Corresponding author), Yong Huang, and Liqun Sun. "Wearable optical coherence tomography angiography probe for freely moving mice." Biomedical Optics Express 14, no. 12 (2023): 6509-6520. [PDF]

  • Zhao, Jingjing, Yonatan Winetraub, Edwin Yuan, Warren H. Chan, Sumaira Z. Aasi, Kavita Y. Sarin, Orr Zohar, and Adam de la Zerda. "Angular compounding for speckle reduction in optical coherence tomography using geometric image registration algorithm and digital focusing." Scientific Reports 10, no. 1 (2020): 1893. [PDF]

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